Descrição
PN: SC-32272
Marca: Santa Cruz
CD71 Antibody (3B8 2A1) is a high quality monoclonal CD71 antibody (also designated p90 antibody, TFRC antibody, TfR1 antibody or Transferrin antibody) suitable for the detection of the CD71 protein of human origin. CD71 Antibody (3B8 2A1) is available as both the non-conjugated anti-CD71 antibody form, as well as multiple conjugated forms of anti-CD71 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. CD71, also known as the transferrin receptor (TFR), is a type II membrane glycoprotein that exists as a disulfide-linked homodimer of two identical subunits. CD71 binds to two molecules of transferrin and a serum iron-transport protein, and directs the cellular uptake of iron via receptor-mediated endocytosis. CD71 is expressed, typically at high levels, on all proliferating cells, reticulocytes and erythroid precursors. It is not expressed on resting leukocytes, but is upregulated upon activation of lymphocytes, monocytes and macrophages. CD71 is also found on most dividing cells and on brain endothelium. A second transferrin receptor, TFR2, also mediates the uptake of transferrin-bound iron. TFR2 is a two-subunit homodimer and is highly expressed in liver as well as in hepatocytes and erythroid precursors. Mutations in the TFR2 gene result in hereditary hemochromatosis type III (HFE3), an iron overloading disorder predominant in Caucasians.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
