Descrição
PN: SC-515727
Marca: Santa Cruz
TMPRSS2 Antibody (H-4) is a high quality monoclonal TMPRSS2 antibody (also designated PRSS10 antibody or Transmembrane protease serine 2 antibody) suitable for the detection of the TMPRSS2 protein of mouse, rat and human origin. TMPRSS2 Antibody (H-4) is available as both the non-conjugated anti-TMPRSS2 antibody form, as well as multiple conjugated forms of anti-TMPRSS2 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. Extracellular proteases mediate the digestion of neighboring extracellular matrix components in initial tumor growth, allow desquamation of tumor cells into the surrounding environment, provide the basis for invasion of basement membranes in targeted metastatic organs and are required for release and activation of many growth and angiogenic factors. The TMPRSS2 gene encodes a 492 amino acid multimeric serine protease, which is mainly expressed in the mouse prostate and kidney, and is also expressed in the human small intestine, prostate, colon, stomach and salivary gland. TMPRSS2 contains several domains, including a serine protease domain of the S1 family, a scavenger receptor cysteine-rich domain of group A, an LDL receptor class A domain and a transmembrane domain. TMPRSS2 is expressed as a full length form and a cleaved protease domain and its expression is increased by androgenic hormones. TMPRSS2 is also expressed in prostate carcinoma, suggesting that it may play a role in prostate carcinogenesis.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
