Descrição
PN: SC-32790
Marca: Santa Cruz
galectin-3 Antibody (B2C10) is a high quality monoclonal galectin-3 antibody (also designated LGALS3 antibody, GAL3 antibody, or Galectin 3 antibody) suitable for the detection of the galectin-3 protein of mouse, rat and human origin. galectin-3 Antibody (B2C10) is available as both the non-conjugated anti-galectin-3 antibody form, as well as multiple conjugated forms of anti-galectin-3 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. Galectins are a family of soluble b-galactoside-binding animal lectins that modulate cell-to-cell adhesion and cell-to-extracellular matrix (ECM) inter- actions and play a role in tumor progression, pre-mRNA splicing and apop-tosis. The galectin-3 protein, also known as Mac-2, hMac-2, GALBP, CBP35 or LGALS3, contains a single carbohydrate binding domain, which binds galactose-containing glycoconjugates. Galectin-3 is expressed in colonic and intestinal epithelium, inflammatory macrophages, papillary and follicular carcinomas, neoplastic astrocytes and some B and T lymphocytes. Upregulated expression of galectin-3 is involved in cancer progression and metastasis. Galectin-3 mediates the endocytosis of β1 Integrins in a lactose-dependent manner and is associated with thyroid malignancy and Crohn′s disease. It may also be used as a marker for diagnosing cases involving Hurthle cell adenomas and carcinomas.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
